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The Value of Contrast-Enhanced Ultrasonography and Contrast-Enhanced CT in the Diagnosis of Malignant Renal Cystic Lesions: A Meta-Analysis

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  • Dong Lan
  • Hong-Chen Qu
  • Ning Li
  • Xing-Wang Zhu
  • Yi-Li Liu
  • Chun-Lai Liu

Abstract

We compared the efficacy of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) for the diagnosis of renal cystic lesions via a meta-analysis to determine the value of CEUS in the prediction of the malignant potential of complex renal cysts. Eleven studies were evaluated: 4 control studies related to CEUS and CECT, 3 studies related to CEUS and 4 studies related to CECT. According to the random effects model, the pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for CEUS/CECT were 0.95/0.90, 0.79/0.85, 4.39/5.00, and 0.10/0.15, respectively. The areas under the summary receiver operating characteristic (AUCs-SROC) curves for the two methods were 94.24% and 93.39%, and the estimated Q values were 0.8805 and 0.8698, respectively. Comparing the Q index values of CEUS and CECT revealed no significant difference between the two methods (P>0.05). When compared with conventional CECT, CEUS is also useful for diagnosing renal cystic lesions in the clinic.

Suggested Citation

  • Dong Lan & Hong-Chen Qu & Ning Li & Xing-Wang Zhu & Yi-Li Liu & Chun-Lai Liu, 2016. "The Value of Contrast-Enhanced Ultrasonography and Contrast-Enhanced CT in the Diagnosis of Malignant Renal Cystic Lesions: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0155857
    DOI: 10.1371/journal.pone.0155857
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