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Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study

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  • Minxue Shen
  • Hongzhuan Tan
  • Shujin Zhou
  • Ravi Retnakaran
  • Graeme N Smith
  • Sandra T Davidge
  • Jacquetta Trasler
  • Mark C Walker
  • Shi Wu Wen

Abstract

Background: It has been reported that higher folate intake from food and supplementation is associated with decreased blood pressure (BP). The association between serum folate concentration and BP has been examined in few studies. We aim to examine the association between serum folate and BP levels in a cohort of young Chinese women. Methods: We used the baseline data from a pre-conception cohort of women of childbearing age in Liuyang, China, for this study. Demographic data were collected by structured interview. Serum folate concentration was measured by immunoassay, and homocysteine, blood glucose, triglyceride and total cholesterol were measured through standardized clinical procedures. Multiple linear regression and principal component regression model were applied in the analysis. Results: A total of 1,532 healthy normotensive non-pregnant women were included in the final analysis. The mean concentration of serum folate was 7.5 ± 5.4 nmol/L and 55% of the women presented with folate deficiency (

Suggested Citation

  • Minxue Shen & Hongzhuan Tan & Shujin Zhou & Ravi Retnakaran & Graeme N Smith & Sandra T Davidge & Jacquetta Trasler & Mark C Walker & Shi Wu Wen, 2016. "Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-9, May.
    • Handle: RePEc:plo:pone00:0155801
    DOI: 10.1371/journal.pone.0155801
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