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Global Variability in Reported Mortality for Critical Illness during the 2009-10 Influenza A(H1N1) Pandemic: A Systematic Review and Meta-Regression to Guide Reporting of Outcomes during Disease Outbreaks

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  • Abhijit Duggal
  • Ruxandra Pinto
  • Gordon Rubenfeld
  • Robert A Fowler

Abstract

Purpose: To determine how patient, healthcare system and study-specific factors influence reported mortality associated with critical illness during the 2009–2010 Influenza A (H1N1) pandemic. Methods: Systematic review with meta-regression of studies reporting on mortality associated with critical illness during the 2009–2010 Influenza A (H1N1) pandemic. Data Sources: Medline, Embase, LiLACs and African Index Medicus to June 2009-March 2016. Results: 226 studies from 50 countries met our inclusion criteria. Mortality associated with H1N1-related critical illness was 31% (95% CI 28–34). Reported mortality was highest in South Asia (61% [95% CI 50–71]) and Sub-Saharan Africa (53% [95% CI 29–75]), in comparison to Western Europe (25% [95% CI 22–30]), North America (25% [95% CI 22–27]) and Australia (15% [95% CI 13–18]) (P

Suggested Citation

  • Abhijit Duggal & Ruxandra Pinto & Gordon Rubenfeld & Robert A Fowler, 2016. "Global Variability in Reported Mortality for Critical Illness during the 2009-10 Influenza A(H1N1) Pandemic: A Systematic Review and Meta-Regression to Guide Reporting of Outcomes during Disease Outbr," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0155044
    DOI: 10.1371/journal.pone.0155044
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