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Increased Risk of Post-Thrombolysis Intracranial Hemorrhage in Acute Ischemic Stroke Patients with Leukoaraiosis: A Meta-Analysis

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  • Qianqian Lin
  • Zhong Li
  • Rui Wei
  • Qingfeng Lei
  • Yunyun Liu
  • Xiaodong Cai

Abstract

Background: Leukoaraiosis is common in patients with acute ischemic stroke. The results from many studies investigating the association between leukoaraiosis and intracranial hemorrhage after thrombolysis remain conflicting. Methods: A meta-analysis was performed to compare the risk of post-thrombolytic intracranial hemorrhage in patients with and without leukoaraiosis. Relevant reports were identified by searching PubMed, EmBase, Cochrane Library, and ISI Web of Science through December 2015 using a combination of subjective and random terms. Eligible studies that were original articles with a clear definition of leukoaraiosis and intracranial hemorrhage were selected and analyzed. Funnel plots, Egger’s test, and Begg’s test were conducted to assess the publication bias. Sensitivity analysis was also performed to evaluate the influence of each individual study. Results: Eleven trials that enrolled 6912 participants were included. There was a significantly increased risk for acute ischemic stroke patients with leukoaraiosis (odds ratio: 1.89, 95% confidence interval 1.51–2.37, P

Suggested Citation

  • Qianqian Lin & Zhong Li & Rui Wei & Qingfeng Lei & Yunyun Liu & Xiaodong Cai, 2016. "Increased Risk of Post-Thrombolysis Intracranial Hemorrhage in Acute Ischemic Stroke Patients with Leukoaraiosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-12, April.
    • Handle: RePEc:plo:pone00:0153486
    DOI: 10.1371/journal.pone.0153486
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