IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0152585.html
   My bibliography  Save this article

The Association between EGFR and cMET Expression and Phosphorylation and Its Prognostic Implication in Patients with Breast Cancer

Author

Listed:
  • Young Kwang Chae
  • Debora de Melo Gagliato
  • Sachin Gopalkrishna Pai
  • Benedito Carneiro
  • Nisha Mohindra
  • Francis Joseph Giles
  • Praveen Ramakrishnan-Geethakumari
  • Joohyuk Sohn
  • Shuying Liu
  • Huiqin Chen
  • Naoto Ueno
  • Gabriel Hortobagyi
  • Ana Maria Gonzalez-Angulo

Abstract

EGFR and cMET cross-talk is involved in breast cancer (BC) progression and resistance to different targeted therapies, however little is known about the co-expression patterns of EGFR and cMET or its prognostic significance in BC. Protein levels of EGFR, cMET and their phosphorylated proteins were measured in 825 BC samples using reverse phase protein array (RPPA). Given unimodal distribution of proteins, the median was selected as a cut-off after sensitivity analyses. Kaplan-Meier survival curves were used to estimate relapse-free (RFS) and overall survival (OS). Cox-proportional hazards models were utilized to determine associations between EGFR and cMET with outcomes. Mean age was 58 years with 457 (55%) hormone receptor (HR) positive, 211 (26%) triple-negative (TN) and 148 (18%) HER2 positive tumors (HER2+). HER2+ was associated with higher EGFR expression and phosphorylation, compared to HR and TN (p

Suggested Citation

  • Young Kwang Chae & Debora de Melo Gagliato & Sachin Gopalkrishna Pai & Benedito Carneiro & Nisha Mohindra & Francis Joseph Giles & Praveen Ramakrishnan-Geethakumari & Joohyuk Sohn & Shuying Liu & Huiq, 2016. "The Association between EGFR and cMET Expression and Phosphorylation and Its Prognostic Implication in Patients with Breast Cancer," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-12, April.
    • Handle: RePEc:plo:pone00:0152585
    DOI: 10.1371/journal.pone.0152585
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152585
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152585&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0152585?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0152585. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.