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Central Pressure Appraisal: Clinical Validation of a Subject-Specific Mathematical Model

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Listed:
  • Francesco Tosello
  • Andrea Guala
  • Dario Leone
  • Carlo Camporeale
  • Giulia Bruno
  • Luca Ridolfi
  • Franco Veglio
  • Alberto Milan

Abstract

Introduction: Current evidence suggests that aortic blood pressure has a superior prognostic value with respect to brachial pressure for cardiovascular events, but direct measurement is not feasible in daily clinical practice. Aim: The aim of the present study is the clinical validation of a multiscale mathematical model for non-invasive appraisal of central blood pressure from subject-specific characteristics. Methods: A total of 51 young male were selected for the present study. Aortic systolic and diastolic pressure were estimated with a mathematical model and were compared to the most-used non-invasive validated technique (SphygmoCor device, AtCor Medical, Australia). SphygmoCor was calibrated through diastolic and systolic brachial pressure obtained with a sphygmomanometer, while model inputs consist of brachial pressure, height, weight, age, left-ventricular end-systolic and end-diastolic volumes, and data from a pulse wave velocity study. Results: Model-estimated systolic and diastolic central blood pressures resulted to be significantly related to SphygmoCor-assessed central systolic (r = 0.65 p

Suggested Citation

  • Francesco Tosello & Andrea Guala & Dario Leone & Carlo Camporeale & Giulia Bruno & Luca Ridolfi & Franco Veglio & Alberto Milan, 2016. "Central Pressure Appraisal: Clinical Validation of a Subject-Specific Mathematical Model," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0151523
    DOI: 10.1371/journal.pone.0151523
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    References listed on IDEAS

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    1. R. G. Newton & D. J. Spurrell, 1967. "A Development of Multiple Regression for the Analysis of Routine Data," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 16(1), pages 51-64, March.
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