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Timed Rise from Floor as a Predictor of Disease Progression in Duchenne Muscular Dystrophy: An Observational Study

Author

Listed:
  • Elena S Mazzone
  • Giorgia Coratti
  • Maria Pia Sormani
  • Sonia Messina
  • Marika Pane
  • Adele D'Amico
  • Giulia Colia
  • Lavinia Fanelli
  • Angela Berardinelli
  • Alice Gardani
  • Valentina Lanzillotta
  • Paola D’Ambrosio
  • Roberta Petillo
  • Filippo Cavallaro
  • Silvia Frosini
  • Luca Bello
  • Serena Bonfiglio
  • Roberto De Sanctis
  • Enrica Rolle
  • Nicola Forcina
  • Francesca Magri
  • Gianluca Vita
  • Concetta Palermo
  • Maria Alice Donati
  • Elena Procopio
  • Maria Teresa Arnoldi
  • Giovanni Baranello
  • Tiziana Mongini
  • Antonella Pini
  • Roberta Battini
  • Elena Pegoraro
  • Yvan Torrente
  • Stefano C Previtali
  • Claudio Bruno
  • Luisa Politano
  • Giacomo P Comi
  • Maria Grazia D’Angelo
  • Enrico Bertini
  • Eugenio Mercuri

Abstract

Background: The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys. Subjects and methods: A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS). Results: The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p

Suggested Citation

  • Elena S Mazzone & Giorgia Coratti & Maria Pia Sormani & Sonia Messina & Marika Pane & Adele D'Amico & Giulia Colia & Lavinia Fanelli & Angela Berardinelli & Alice Gardani & Valentina Lanzillotta & Pao, 2016. "Timed Rise from Floor as a Predictor of Disease Progression in Duchenne Muscular Dystrophy: An Observational Study," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0151445
    DOI: 10.1371/journal.pone.0151445
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