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Differential Evolutionary Selection and Natural Evolvability Observed in ALT Proteins of Human Filarial Parasites

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  • Neil C Devoe
  • Ian J Corbett
  • Linsey Barker
  • Robert Chang
  • Polyxeni Gudis
  • Nathan Mullen
  • Kailey Perez
  • Hugo Raposo
  • John Scholz
  • Meghan May

Abstract

The abundant larval transcript (ALT-2) protein is present in all members of the Filarioidea, and has been reported as a potential candidate antigen for a subunit vaccine against lymphatic filariasis. To assess the potential for vaccine escape or heterologous protection, we examined the evolutionary selection acting on ALT-2. The ratios of nonsynonymous (K(a)) to synonymous (K(s)) mutation frequencies (ω) were calculated for the alt-2 genes of the lymphatic filariasis agents Brugia malayi and Wuchereria bancrofti and the agents of river blindness and African eyeworm disease Onchocerca volvulus and Loa loa. Two distinct Bayesian models of sequence evolution showed that ALT-2 of W. bancrofti and L. loa were under significant (P

Suggested Citation

  • Neil C Devoe & Ian J Corbett & Linsey Barker & Robert Chang & Polyxeni Gudis & Nathan Mullen & Kailey Perez & Hugo Raposo & John Scholz & Meghan May, 2016. "Differential Evolutionary Selection and Natural Evolvability Observed in ALT Proteins of Human Filarial Parasites," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-14, February.
    • Handle: RePEc:plo:pone00:0148611
    DOI: 10.1371/journal.pone.0148611
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