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Adjusted Age-Adjusted Charlson Comorbidity Index Score as a Risk Measure of Perioperative Mortality before Cancer Surgery

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  • Chun-Ming Chang
  • Wen-Yao Yin
  • Chang-Kao Wei
  • Chin-Chia Wu
  • Yu-Chieh Su
  • Chia-Hui Yu
  • Ching-Chih Lee

Abstract

Background: Identification of patients at risk of death from cancer surgery should aid in preoperative preparation. The purpose of this study is to assess and adjust the age-adjusted Charlson comorbidity index (ACCI) to identify cancer patients with increased risk of perioperative mortality. Methods: We identified 156,151 patients undergoing surgery for one of the ten common cancers between 2007 and 2011 in the Taiwan National Health Insurance Research Database. Half of the patients were randomly selected, and a multivariate logistic regression analysis was used to develop an adjusted-ACCI score for estimating the risk of 90-day mortality by variables from the original ACCI. The score was validated. The association between the score and perioperative mortality was analyzed. Results: The adjusted-ACCI score yield a better discrimination on mortality after cancer surgery than the original ACCI score, with c-statics of 0.75 versus 0.71. Over 80 years of age, 70–80 years, and renal disease had the strongest impact on mortality, hazard ratios 8.40, 3.63, and 3.09 (P

Suggested Citation

  • Chun-Ming Chang & Wen-Yao Yin & Chang-Kao Wei & Chin-Chia Wu & Yu-Chieh Su & Chia-Hui Yu & Ching-Chih Lee, 2016. "Adjusted Age-Adjusted Charlson Comorbidity Index Score as a Risk Measure of Perioperative Mortality before Cancer Surgery," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-16, February.
    • Handle: RePEc:plo:pone00:0148076
    DOI: 10.1371/journal.pone.0148076
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