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Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome

Author

Listed:
  • Yanhua Wu
  • Yaqin Yu
  • Tiancheng Zhao
  • Shibin Wang
  • Yingli Fu
  • Yue Qi
  • Guang Yang
  • Wenwang Yao
  • Yingying Su
  • Yue Ma
  • Jieping Shi
  • Jing Jiang
  • Changgui Kou

Abstract

Objective: The present study investigated the prevalence and risk factors for Metabolic syndrome. We evaluated the association between single nucleotide polymorphisms (SNPs) in the apolipoprotein APOA1/C3/A4/A5 gene cluster and the MetS risk and analyzed the interactions of environmental factors and APOA1/C3/A4/A5 gene cluster polymorphisms with MetS. Methods: A study on the prevalence and risk factors for MetS was conducted using data from a large cross-sectional survey representative of the population of Jilin Province situated in northeastern China. A total of 16,831 participations were randomly chosen by multistage stratified cluster sampling of residents aged from 18 to 79 years in all nine administrative areas of the province. Environmental factors associated with MetS were examined using univariate and multivariate logistic regression analyses based on the weighted sample data. A sub-sample of 1813 survey subjects who met the criteria for MetS patients and 2037 controls from this case-control study were used to evaluate the association between SNPs and MetS risk. Genomic DNA was extracted from peripheral blood lymphocytes, and SNP genotyping was determined by MALDI-TOF-MS. The associations between SNPs and MetS were examined using a case-control study design. The interactions of environmental factors and APOA1/C3/A4/A5 gene cluster polymorphisms with MetS were assessed using multivariate logistic regression analysis. Results: The overall adjusted prevalence of MetS was 32.86% in Jilin province. The prevalence of MetS in men was 36.64%, which was significantly higher than the prevalence in women (29.66%). MetS was more common in urban areas (33.86%) than in rural areas (31.80%). The prevalence of MetS significantly increased with age (OR = 8.621, 95%CI = 6.594–11.272). Mental labor (OR = 1.098, 95%CI = 1.008–1.195), current smoking (OR = 1.259, 95%CI = 1.108–1.429), excess salt intake (OR = 1.252, 95%CI = 1.149–1.363), and a fruit and dairy intake less than 2 servings a week were positively associated with MetS (P

Suggested Citation

  • Yanhua Wu & Yaqin Yu & Tiancheng Zhao & Shibin Wang & Yingli Fu & Yue Qi & Guang Yang & Wenwang Yao & Yingying Su & Yue Ma & Jieping Shi & Jing Jiang & Changgui Kou, 2016. "Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-17, January.
    • Handle: RePEc:plo:pone00:0147946
    DOI: 10.1371/journal.pone.0147946
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    References listed on IDEAS

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    1. Chunxiao Xu & Rongpan Bai & Dandan Zhang & Zhenli Li & Honghong Zhu & Maode Lai & Yimin Zhu, 2013. "Effects of APOA5 −1131T>C (rs662799) on Fasting Plasma Lipids and Risk of Metabolic Syndrome: Evidence from a Case-Control Study in China and a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-1, February.
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