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Association of Forced Vital Capacity with the Developmental Gene NCOR2

Author

Listed:
  • Cosetta Minelli
  • Charlotte H Dean
  • Matthew Hind
  • Alexessander Couto Alves
  • André F S Amaral
  • Valerie Siroux
  • Ville Huikari
  • María Soler Artigas
  • David M Evans
  • Daan W Loth
  • Yohan Bossé
  • Dirkje S Postma
  • Don Sin
  • John Thompson
  • Florence Demenais
  • John Henderson
  • SpiroMeta consortium
  • CHARGE consortium
  • Emmanuelle Bouzigon
  • Deborah Jarvis
  • Marjo-Riitta Järvelin
  • Peter Burney

Abstract

Background: Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes. Methods: Per-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 children (ALSPAC). Associations were considered replicated if the replication p-value survived Bonferroni correction (p

Suggested Citation

  • Cosetta Minelli & Charlotte H Dean & Matthew Hind & Alexessander Couto Alves & André F S Amaral & Valerie Siroux & Ville Huikari & María Soler Artigas & David M Evans & Daan W Loth & Yohan Bossé & Dir, 2016. "Association of Forced Vital Capacity with the Developmental Gene NCOR2," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-17, February.
    • Handle: RePEc:plo:pone00:0147388
    DOI: 10.1371/journal.pone.0147388
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