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Astrocyte Elevated Gene-1 as a Novel Clinicopathological and Prognostic Biomarker for Gastrointestinal Cancers: A Meta-Analysis with 2999 Patients

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  • Yihuan Luo
  • Xin Zhang
  • Zhong Tan
  • Peirong Wu
  • Xuelian Xiang
  • Yiwu Dang
  • Gang Chen

Abstract

Background: There have been numerous articles as to whether the staining index (SI) of astrocyte elevated gene-1 (AEG-1) adversely affects clinical progression and prognosis of gastrointestinal cancers. Nevertheless, controversy still exists in terms of correlations between AEG-1 SI and clinicopathological parameters including survival data. Consequently, we conducted a comprehensive meta-analysis to confirm the role of AEG-1 in clinical outcomes of gastrointestinal carcinoma patients. Methods: We performed a comprehensive search in PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, EMBASE, Science Direct, Wiley Online Library, China National Knowledge Infrastructure (CNKI), WanFang and Chinese VIP databases. STATA 12.0 (STATA Corp., College, TX) was used to analyze the data extracted from suitable studies and Newcastle-Ottawa Scale was applied to assess the quality of included articles. Results: The current meta-analysis included 2999 patients and our results suggested that strong associations emerged between AEG-1 SI and histological differentiation (OR = 2.129, 95%CI: 1.377–3.290, P = 0.001), tumor (T) classification (OR = 2.272, 95%CI: 1.147–4.502, P = 0.019), lymph node (N) classification (OR = 2.696, 95%CI: 2.178–3.337, P

Suggested Citation

  • Yihuan Luo & Xin Zhang & Zhong Tan & Peirong Wu & Xuelian Xiang & Yiwu Dang & Gang Chen, 2015. "Astrocyte Elevated Gene-1 as a Novel Clinicopathological and Prognostic Biomarker for Gastrointestinal Cancers: A Meta-Analysis with 2999 Patients," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-16, December.
    • Handle: RePEc:plo:pone00:0145659
    DOI: 10.1371/journal.pone.0145659
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    Cited by:

    1. Layane Barreto Costa & Lucas Solon Dias de Farias & Noele Gurgel d’à vila & Irami Araújo-Neto & Francisco Irochima Pinheiro & Eduardo Pereira de Azevedo & Amália Cinthia Meneses do Rêgo & Fausto , 2017. "Gastric Cancer: Biological Markers as Prognostic Factor," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 8(2), pages 41-48, December.

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