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Prediction of Maternal Cytomegalovirus Serostatus in Early Pregnancy: A Retrospective Analysis in Western Europe

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  • Lorenz Kuessel
  • Heinrich Husslein
  • Julian Marschalek
  • Julia Brunner
  • Robin Ristl
  • Theresia Popow-Kraupp
  • Herbert Kiss

Abstract

Background: Cytomegalovirus (CMV) is the most prevalent congenital viral infection and thus places an enormous disease burden on newborn infants. Seroprevalence of maternal antibodies to CMV due to CMV exposure prior to pregnancy is currently the most important protective factor against congenital CMV disease. The aim of this study was to identify potential predictors, and to develop and evaluate a risk-predicting model for the maternal CMV serostatus in early pregnancy. Methods: Maternal and paternal background information, as well as maternal CMV serostatus in early pregnancy from 882 pregnant women were analyzed. Women were divided into two groups based on their CMV serostatus, and were compared using univariate analysis. To predict serostatus based on epidemiological baseline characteristics, a multiple logistic regression model was calculated using stepwise model selection. Sensitivity and specificity were analyzed using ROC curves. A nomogram based on the model was developed. Results: 646 women were CMV seropositive (73.2%), and 236 were seronegative (26.8%). The groups differed significantly with respect to maternal age (p = 0.006), gravidity (p

Suggested Citation

  • Lorenz Kuessel & Heinrich Husslein & Julian Marschalek & Julia Brunner & Robin Ristl & Theresia Popow-Kraupp & Herbert Kiss, 2015. "Prediction of Maternal Cytomegalovirus Serostatus in Early Pregnancy: A Retrospective Analysis in Western Europe," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0145470
    DOI: 10.1371/journal.pone.0145470
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