IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0144997.html
   My bibliography  Save this article

Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium

Author

Listed:
  • Abbas Dehghan
  • Joshua C Bis
  • Charles C White
  • Albert Vernon Smith
  • Alanna C Morrison
  • L Adrienne Cupples
  • Stella Trompet
  • Daniel I Chasman
  • Thomas Lumley
  • Uwe Völker
  • Brendan M Buckley
  • Jingzhong Ding
  • Majken K Jensen
  • Aaron R Folsom
  • Stephen B Kritchevsky
  • Cynthia J Girman
  • Ian Ford
  • Marcus Dörr
  • Veikko Salomaa
  • André G Uitterlinden
  • Gudny Eiriksdottir
  • Ramachandran S Vasan
  • Nora Franceschini
  • Cara L Carty
  • Jarmo Virtamo
  • Serkalem Demissie
  • Philippe Amouyel
  • Dominique Arveiler
  • Susan R Heckbert
  • Jean Ferrières
  • Pierre Ducimetière
  • Nicholas L Smith
  • Ying A Wang
  • David S Siscovick
  • Kenneth M Rice
  • Per-Gunnar Wiklund
  • Kent D Taylor
  • Alun Evans
  • Frank Kee
  • Jerome I Rotter
  • Juha Karvanen
  • Kari Kuulasmaa
  • Gerardo Heiss
  • Peter Kraft
  • Lenore J Launer
  • Albert Hofman
  • Marcello R P Markus
  • Lynda M Rose
  • Kaisa Silander
  • Peter Wagner
  • Emelia J Benjamin
  • Kurt Lohman
  • David J Stott
  • Fernando Rivadeneira
  • Tamara B Harris
  • Daniel Levy
  • Yongmei Liu
  • Eric B Rimm
  • J Wouter Jukema
  • Henry Völzke
  • Paul M Ridker
  • Stefan Blankenberg
  • Oscar H Franco
  • Vilmundur Gudnason
  • Bruce M Psaty
  • Eric Boerwinkle
  • Christopher J O'Donnell

Abstract

Background: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods: We performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10−6 in Stage I were taken to Stage II for further discovery. Furthermore, in an analysis of prognosis, we studied whether known SNPs from former GWAS were associated with total mortality in individuals who experienced MI during follow-up. Results: In Stage I 15 loci passed the threshold of 5×10−6; 8 loci for MI and 8 loci for CHD, for which one locus overlapped and none were reported in previous GWAS meta-analyses. We took 60 SNPs representing these 15 loci to Stage II of discovery. Four SNPs near QKI showed nominally significant association with MI (p-value

Suggested Citation

  • Abbas Dehghan & Joshua C Bis & Charles C White & Albert Vernon Smith & Alanna C Morrison & L Adrienne Cupples & Stella Trompet & Daniel I Chasman & Thomas Lumley & Uwe Völker & Brendan M Buckley & Jin, 2016. "Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0144997
    DOI: 10.1371/journal.pone.0144997
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144997
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144997&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0144997?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yi Sun & Shuna Huang & Qing Huang & Shaowei Lin & Siying Wu & Guiqing Wu & Qishuang Ruan & Tingxing Zhang & Huangyuan Li, 2018. "Microarray Analysis of Differentially Expressed LncRNAs with Associated Co-Expression and CeRNA Networks in Coronary Heart Disease," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 3(2), pages 3197-3207, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0144997. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.