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Acute Myocardial Infarction Risk in Patients with Coronary Artery Disease Doubled after Upper Gastrointestinal Tract Bleeding: A Nationwide Nested Case-Control Study

Author

Listed:
  • Chia-Jung Wu
  • Hung-Jung Lin
  • Shih-Feng Weng
  • Chien-Chin Hsu
  • Jhi-Joung Wang
  • Shih-Bin Su
  • Chien-Cheng Huang
  • How-Ran Guo

Abstract

Prior studies of upper gastrointestinal bleeding (UGIB) and acute myocardial infarction (AMI) are small, and long-term effects of UGIB on AMI have not been delineated. We investigated whether UGIB in patients diagnosed with coronary artery disease (CAD) increased their risk of subsequent AMI. This was a population-based, nested case-control study using Taiwan’s National Health Insurance Research Database. After propensity-score matching for age, gender, comorbidities, CAD date, and follow-up duration, we identified 1,677 new-onset CAD patients with AMI (AMI[+]) between 2001 and 2006 as the case group and 10,062 new-onset CAD patients without (AMI[−]) as the control group. Conditional logistic regression was used to examine the association between UGIB and AMI. Compared with UGIB[−] patients, UGIB[+] patients had twice the risk for subsequent AMI (adjusted odds ratio [AOR] = 2.08; 95% confidence interval [CI], 1.72–2.50). In the subgroup analysis for gender and age, UGIB[+] women (AOR = 2.70; 95% CI, 2.03–3.57) and patients

Suggested Citation

  • Chia-Jung Wu & Hung-Jung Lin & Shih-Feng Weng & Chien-Chin Hsu & Jhi-Joung Wang & Shih-Bin Su & Chien-Cheng Huang & How-Ran Guo, 2015. "Acute Myocardial Infarction Risk in Patients with Coronary Artery Disease Doubled after Upper Gastrointestinal Tract Bleeding: A Nationwide Nested Case-Control Study," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0142000
    DOI: 10.1371/journal.pone.0142000
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