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A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010

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  • Shin Hye Kim
  • Kyoung Huh
  • Sungho Won
  • Kuk-Wha Lee
  • Mi-Jung Park

Abstract

Background: Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. Methods: Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children, including those registered with a diagnosis of CPP for the first time and those diagnosed with CPP who were treated with gonadotropin-releasing hormone analogs. Results: The prevalence of CPP was 55.9 per 100,000 girls and 1.7 per 100,000 boys, respectively. The overall incidence of CPP was 15.3 per 100,000 girls, and 0.6 per 100,000 boys. The annual incidence of CPP in girls significantly increased from 3.3 to 50.4 per 100,000 girls; whereas in boys, it gradually increased from 0.3 to 1.2 per 100,000 boys. The annual incidence of CPP in girls consistently increased at all ages year by year, with greater increases at older ages (≥6 years of age), and smaller increases in girls aged

Suggested Citation

  • Shin Hye Kim & Kyoung Huh & Sungho Won & Kuk-Wha Lee & Mi-Jung Park, 2015. "A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0141844
    DOI: 10.1371/journal.pone.0141844
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    Cited by:

    1. Pen-Hua Su & Jing-Yang Huang & Cho-Shun Li & Hua-Pin Chang, 2020. "The Age Distribution among Children Seeking Medical Treatment for Precocious Puberty in Taiwan," IJERPH, MDPI, vol. 17(18), pages 1-12, September.

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