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Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study

Author

Listed:
  • Shozo Yano
  • Atsushi Nagai
  • Minoru Isomura
  • Masayuki Yamasaki
  • Tsunetaka Kijima
  • Miwako Takeda
  • Tsuyoshi Hamano
  • Toru Nabika

Abstract

Objectives: Myostatin (MSTN), a member of TGF-β superfamily, is produced in the skeletal muscle to inhibit myocyte differentiation. MSTN expression is increased in the skeletal muscle in patients with chronic kidney disease (CKD), which may play a role in the pathogenesis of sarcopenia or in the protein energy wasting (PEW). This observation implies that the plasma MSTN level may be correlated with kidney function. Thus, we conducted a cross-sectional study to evaluate the association between the plasma MSTN concentration and the estimated glomerular filtration rate (eGFR). Subjects and Methods: Subjects were 781 participants of a health examination performed in a rural area in Japan. Among them, 124 subjects were selected by stratified random sampling according to eGFR. Creatinine clearance (ClCr) by the Cockcroft-Gault equation was used as a measure of kidney function. Plasma concentration of MSTN was determined by ELISA. Results: The plasma MSTN level was not different between men (3.42±1.61 ng/mL) and women (3.27±1.43 ng/mL). In a simple regression analysis, the MSTN level was significantly correlated with eGFR (r = -0.25, p

Suggested Citation

  • Shozo Yano & Atsushi Nagai & Minoru Isomura & Masayuki Yamasaki & Tsunetaka Kijima & Miwako Takeda & Tsuyoshi Hamano & Toru Nabika, 2015. "Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-9, October.
    • Handle: RePEc:plo:pone00:0141035
    DOI: 10.1371/journal.pone.0141035
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    Cited by:

    1. Soo Jeong Choi & Min Sung Lee & Duk-Hee Kang & Gang Jee Ko & Hee-Sook Lim & Byung Chul Yu & Moo Yong Park & Jin Kuk Kim & Chul-Hee Kim & Seung Duk Hwang & Jun Chul Kim & Chang Won Won & Won Suk An, 2021. "Myostatin/Appendicular Skeletal Muscle Mass (ASM) Ratio, Not Myostatin, Is Associated with Low Handgrip Strength in Community-Dwelling Older Women," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    2. Rie Fukuoka & Miwako Takeda & Takafumi Abe & Masayuki Yamasaki & Shinji Kimura & Kenta Okuyama & Minoru Isomura & Toru Nabika, 2021. "Inconvenience of Living Place Affects Individual HbA1c Level in a Rural Area in Japan: Shimane CoHRE Study," IJERPH, MDPI, vol. 18(3), pages 1-9, January.

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