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Association of Cardiovascular Risk Factors with Carotid Intima Media Thickness in Patients with Rheumatoid Arthritis with Low Disease Activity Compared to Controls: A Cross-Sectional Study

Author

Listed:
  • Deborah F van Breukelen—van der Stoep
  • Derkjen van Zeben
  • Boudewijn Klop
  • Gert-Jan M van de Geijn
  • Hans J W Janssen
  • Mieke J M W Hazes
  • Erwin Birnie
  • Noelle van der Meulen
  • Marijke A De Vries
  • Manuel Castro Cabezas

Abstract

Objectives: Rheumatoid arthritis (RA) has been identified as an independent cardiovascular risk factor. The importance of risk factors such as hypertension and hyperlipidemia in the generation of atherosclerosis in RA patients is unclear. This study analyzed clinical parameters associated with carotid intima media thickness (cIMT) in patients with RA. Methods: Subjects with RA and healthy controls without RA, both without known cardiovascular disease, were included. Participants underwent a standard physical examination and laboratory measurements including a lipid profile. cIMT was measured semi-automatically by ultrasound. Results: In total 243 RA patients and 117 controls were included. The median RA disease duration was 7 years (IQR 2–14 years). The median DAS28 was 2.4 (IQR 1.6–3.2) and 114 (50.4%) of the RA patients were in remission. The presence of RA and cIMT were not associated (univariate analysis). Multivariable regression analysis showed that cIMT in RA patients was associated with age (B = 0.006, P

Suggested Citation

  • Deborah F van Breukelen—van der Stoep & Derkjen van Zeben & Boudewijn Klop & Gert-Jan M van de Geijn & Hans J W Janssen & Mieke J M W Hazes & Erwin Birnie & Noelle van der Meulen & Marijke A De Vries , 2015. "Association of Cardiovascular Risk Factors with Carotid Intima Media Thickness in Patients with Rheumatoid Arthritis with Low Disease Activity Compared to Controls: A Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0140844
    DOI: 10.1371/journal.pone.0140844
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    Cited by:

    1. Delia Taverner & Joan-Carles Vallvé & Raimón Ferré & Silvia Paredes & Lluís Masana & Antoni Castro, 2018. "Variables associated with subclinical atherosclerosis in a cohort of rheumatoid arthritis patients: Sex-specific associations and differential effects of disease activity and age," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-12, March.

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