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High Current CD4+ T Cell Count Predicts Suboptimal Adherence to Antiretroviral Therapy

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  • Alexander O Pasternak
  • Marijn de Bruin
  • Margreet Bakker
  • Ben Berkhout
  • Jan M Prins

Abstract

High levels of adherence to antiretroviral therapy (ART) are necessary for achieving and maintaining optimal virological suppression, as suboptimal adherence leads to therapy failure and disease progression. It is well known that adherence to ART predicts therapy response, but it is unclear whether clinical outcomes of ART predict adherence. To examine the predictive power of current CD4+ T cell count for adherence of HIV-infected individuals to ART, we performed a cross-sectional analysis of 133 Dutch HIV patients with electronically measured adherence. In a multivariate analysis adjusting for a number of sociodemographic and clinical variables, high current CD4+ T cell count (>660 cells/mm3) was most strongly associated with lower adherence to ART (assessed as a continuous variable) during a two-month period immediately following the measurements of variables (P = 0.008). The twice-per-day (versus once-per-day) dosing regimen was also significantly associated with lower adherence (P = 0.014). In a second multivariate analysis aimed at determining the predictors of suboptimal (

Suggested Citation

  • Alexander O Pasternak & Marijn de Bruin & Margreet Bakker & Ben Berkhout & Jan M Prins, 2015. "High Current CD4+ T Cell Count Predicts Suboptimal Adherence to Antiretroviral Therapy," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0140791
    DOI: 10.1371/journal.pone.0140791
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