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Serum Adiponectin and Glomerular Filtration Rate in Patients with Type 2 Diabetes

Author

Listed:
  • Lorena Ortega Moreno
  • Olga Lamacchia
  • Massimiliano Copetti
  • Lucia Salvemini
  • Concetta De Bonis
  • Salvatore De Cosmo
  • Mauro Cignarelli
  • Vincenzo Trischitta
  • Claudia Menzaghi

Abstract

High serum adiponectin has been increased in several conditions of kidney disease. Only sparse and conflicting results have been reported in patients with type 2 diabetes (T2D), a subgroup of individuals who are at high risk for renal dysfunction. The aim of this study was to fill up this gap of knowledge by investigating such association in a large sample of Italian diabetic patients. The association between serum adiponectin levels and estimated glomerular filtration rate (eGFR by Chronic Kidney Disease-Epidemiology Collaboration CKD-EPI equation) was investigated in 1,243 patients with T2D from two cross-sectional Italian studies: 878 from San Giovanni Rotondo (SGR) and 365 from Foggia (FG). Serum adiponectin was inversely associated with eGFR in SGR [β (standard error, SE) for 1 standard deviation (SD) of adiponectin = -3.26 (0.64)] and in FG [β(SE)=-5.70(1.28)] sample, as well as in the two studies combined [β(SE)=-3.99(0.59)];(p

Suggested Citation

  • Lorena Ortega Moreno & Olga Lamacchia & Massimiliano Copetti & Lucia Salvemini & Concetta De Bonis & Salvatore De Cosmo & Mauro Cignarelli & Vincenzo Trischitta & Claudia Menzaghi, 2015. "Serum Adiponectin and Glomerular Filtration Rate in Patients with Type 2 Diabetes," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-9, October.
    • Handle: RePEc:plo:pone00:0140631
    DOI: 10.1371/journal.pone.0140631
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