IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0140478.html
   My bibliography  Save this article

Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study

Author

Listed:
  • Tess V Clendenen
  • Wenzhen Ge
  • Karen L Koenig
  • Tomas Axelsson
  • Mengling Liu
  • Yelena Afanasyeva
  • Anne Andersson
  • Alan A Arslan
  • Yu Chen
  • Göran Hallmans
  • Per Lenner
  • Tomas Kirchhoff
  • Eva Lundin
  • Roy E Shore
  • Malin Sund
  • Anne Zeleniuch-Jacquotte

Abstract

Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH)D concentration in GWAS were also associated with plasma 25(OH)D in our study (p-trend

Suggested Citation

  • Tess V Clendenen & Wenzhen Ge & Karen L Koenig & Tomas Axelsson & Mengling Liu & Yelena Afanasyeva & Anne Andersson & Alan A Arslan & Yu Chen & Göran Hallmans & Per Lenner & Tomas Kirchhoff & Eva Lund, 2015. "Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0140478
    DOI: 10.1371/journal.pone.0140478
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140478
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140478&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0140478?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0140478. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.