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Hemodialysis versus Peritoneal Dialysis: A Comparison of Survival Outcomes in South-East Asian Patients with End-Stage Renal Disease

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  • Fan Yang
  • Lay-Wai Khin
  • Titus Lau
  • Horng-Ruey Chua
  • A Vathsala
  • Evan Lee
  • Nan Luo

Abstract

Background: Studies comparing patient survival of hemodialysis (HD) and peritoneal dialysis (PD) have yielded conflicting results and no such study was from South-East Asia. This study aimed to compare the survival outcomes of patients with end-stage renal disease (ESRD) who started dialysis with HD and PD in Singapore. Methods: Survival data for a maximum of 5 years from a single-center cohort of 871 ESRD patients starting dialysis with HD (n = 641) or PD (n = 230) from 2005–2010 was analyzed using the flexible Royston-Parmar (RP) model. The model was also applied to a subsample of 225 propensity-score-matched patient pairs and subgroups defined by age, diabetes mellitus, and cardiovascular disease. Results: After adjusting for the effect of socio-demographic and clinical characteristics, the risk of death was higher in patients initiating dialysis with PD than those initiating dialysis with HD (hazard ratio [HR]: 2.08; 95% confidence interval [CI]: 1.67–2.59; p

Suggested Citation

  • Fan Yang & Lay-Wai Khin & Titus Lau & Horng-Ruey Chua & A Vathsala & Evan Lee & Nan Luo, 2015. "Hemodialysis versus Peritoneal Dialysis: A Comparison of Survival Outcomes in South-East Asian Patients with End-Stage Renal Disease," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0140195
    DOI: 10.1371/journal.pone.0140195
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