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Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice

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  • Bastian Schirmer
  • Dirk Wedekind
  • Silke Glage
  • Detlef Neumann

Abstract

The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRLlpr mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time, lymphadenopathy, constitutive interferon-γ production, and frequency of CD3+B220+ abnormal T cells were without differences. We conclude that in the systemic lupus erythematosus syndrom IL-18 is involved specifically in the renal pathogenesis.

Suggested Citation

  • Bastian Schirmer & Dirk Wedekind & Silke Glage & Detlef Neumann, 2015. "Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0140173
    DOI: 10.1371/journal.pone.0140173
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