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Adjunctive Aripiprazole Treatment for Risperidone-Induced Hyperprolactinemia: An 8-Week Randomized, Open-Label, Comparative Clinical Trial

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Listed:
  • Jingyuan Zhao
  • Xueqin Song
  • Xiaoqing Ai
  • Xiaojing Gu
  • Guangbiao Huang
  • Xue Li
  • Lijuan Pang
  • Minli Ding
  • Shuang Ding
  • Luxian Lv

Abstract

Objective: The present study aimed to evaluate the efficacy and safety of adjunctive aripiprazole treatment in schizophrenia patients with risperidone-induced hyperprolactinemia. Methods: One hundred and thirteen patients who were receiving a stable dose of risperidone were randomly assigned to either adjunctive aripiprazole treatment (10 mg/day) (aripiprazole group) or no additional treatment (control group) at a 1:1 ratio for 8 weeks. Schizophrenia symptoms were measured using the Positive and Negative Syndrome Scale (PANSS). Rating scales and safety assessments (RSESE, BARS, UKU) were performed at baseline and at weeks 4 and 8. Serum levels of prolactin were determined at baseline and at weeks 2, 4, 6 and 8. Metabolic parameters were determined at baseline and again at weeks 4 and 8. Results: One hundred and thirteen patients were enrolled in this study, and 107 patients completed the study (54 in the aripiprazole group, and 53 in the control group). PANSS-total scores in the aripiprazole group decreased significantly at week 4 (P = 0.003) and week 8 (P = 0.007) compared with the control group. PANSS-negative scores in the aripiprazole group also decreased significantly at week 4 (P = 0.005) and week 8 (P

Suggested Citation

  • Jingyuan Zhao & Xueqin Song & Xiaoqing Ai & Xiaojing Gu & Guangbiao Huang & Xue Li & Lijuan Pang & Minli Ding & Shuang Ding & Luxian Lv, 2015. "Adjunctive Aripiprazole Treatment for Risperidone-Induced Hyperprolactinemia: An 8-Week Randomized, Open-Label, Comparative Clinical Trial," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0139717
    DOI: 10.1371/journal.pone.0139717
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