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Multiscale Entropy of the Heart Rate Variability for the Prediction of an Ischemic Stroke in Patients with Permanent Atrial Fibrillation

Author

Listed:
  • Eiichi Watanabe
  • Ken Kiyono
  • Junichiro Hayano
  • Yoshiharu Yamamoto
  • Joji Inamasu
  • Mayumi Yamamoto
  • Tomohide Ichikawa
  • Yoshihiro Sobue
  • Masehide Harada
  • Yukio Ozaki

Abstract

Background: Atrial fibrillation (AF) is a significant risk factor for ischemic strokes, and making a robust risk stratification scheme would be important. Few studies have examined whether nonlinear dynamics of the heart rate could predict ischemic strokes in AF. We examined whether a novel complexity measurement of the heart rate variability called multiscale entropy (MSE) was a useful risk stratification measure of ischemic strokes in patients with permanent AF. Methods and Results: We examined 173 consecutive patients (age 69±11 years) with permanent AF who underwent 24-hour Holter electrocardiography from April 2005 to December 2006. We assessed several frequency ranges of the MSE and CHA2DS2-VASc score (1 point for congestive heart failure, hypertension, diabetes, vascular disease, an age 65 to 74 years, and a female sex and 2 points for an age≥75 years and a stroke or transient ischemic attack). We found 22 (13%) incident ischemic strokes during a mean follow up of 3.8-years. The average value of the MSE in the very-low frequency subrange (90–300 s, MeanEnVLF2) was significantly higher in patients who developed ischemic strokes than in those who did not (0.68±0.15 vs. 0.60±0.14, P

Suggested Citation

  • Eiichi Watanabe & Ken Kiyono & Junichiro Hayano & Yoshiharu Yamamoto & Joji Inamasu & Mayumi Yamamoto & Tomohide Ichikawa & Yoshihiro Sobue & Masehide Harada & Yukio Ozaki, 2015. "Multiscale Entropy of the Heart Rate Variability for the Prediction of an Ischemic Stroke in Patients with Permanent Atrial Fibrillation," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0137144
    DOI: 10.1371/journal.pone.0137144
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