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Effects of Fentanyl on Emergence Agitation in Children under Sevoflurane Anesthesia: Meta-Analysis of Randomized Controlled Trials

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  • Fenmei Shi
  • Ying Xiao
  • Wei Xiong
  • Qin Zhou
  • Peng Yang
  • Xiongqing Huang

Abstract

Background and Objectives: The goal of this meta-analysis study was to assess the effects of fentanyl on emergence agitation (EA) under sevoflurane anesthesia in children. Subjects and Methods: We searched electronic databases (PubMed, Embase, Web of Science and the Cochrane Central Register of Controlled Trials) for articles published until December 2014. Randomized controlled trials (RCTs) that assessed the effects of fentanyl and placebo on EA under sevoflurane anesthesia in children that the outcome were the incidence of EA, postoperative pain, emergence time or adverse effects were included in this meta-analysis. Results: A total of 16 studies, including 1362 patients (737 patients for the fentanyl group and 625 for the placebo group), were evaluated in final analysis. We found that administration of fentanyl decreased the incidences of EA (RR = 0.37, 95% CI 0.27~0.49, P

Suggested Citation

  • Fenmei Shi & Ying Xiao & Wei Xiong & Qin Zhou & Peng Yang & Xiongqing Huang, 2015. "Effects of Fentanyl on Emergence Agitation in Children under Sevoflurane Anesthesia: Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-18, August.
    • Handle: RePEc:plo:pone00:0135244
    DOI: 10.1371/journal.pone.0135244
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