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Use of PCR Signal and Therapeutic Drug Monitoring in a Switch Cohort Study to Tenofovir/Emtricitabine/Rilpivirine: A W96 Follow-Up

Author

Listed:
  • Charlotte Charpentier
  • Minh Patrick Lê
  • Véronique Joly
  • Benoit Visseaux
  • Sylvie Lariven
  • Bao Phung
  • Patrick Yéni
  • Yazdan Yazdanpanah
  • Diane Descamps
  • Gilles Peytavin
  • Roland Landman

Abstract

Objective: To assess, in a clinical cohort, the efficacy of switching treatment in virologically-suppressed patients to tenofovir/emtricitabine/rilpivirine as a single-tablet regimen (STR) using the PCR signal of the viral load (VL) assay and plasma drug determination (C24h). Patients and methods: An observational single-centre study enrolling patients with VL 50 ng/mL, the target effective concentration. Conclusions: In this clinical cohort of virologically-suppressed patients switching to a new STR, most subjects had adequate rilpivirine C24h and displayed a high level of virological suppression with no residual viremia until W96.

Suggested Citation

  • Charlotte Charpentier & Minh Patrick Lê & Véronique Joly & Benoit Visseaux & Sylvie Lariven & Bao Phung & Patrick Yéni & Yazdan Yazdanpanah & Diane Descamps & Gilles Peytavin & Roland Landman, 2015. "Use of PCR Signal and Therapeutic Drug Monitoring in a Switch Cohort Study to Tenofovir/Emtricitabine/Rilpivirine: A W96 Follow-Up," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0134430
    DOI: 10.1371/journal.pone.0134430
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