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Prognostic Fifteen-Gene Signature for Early Stage Pancreatic Ductal Adenocarcinoma

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  • Dung-Tsa Chen
  • Ashley H Davis-Yadley
  • Po-Yu Huang
  • Kazim Husain
  • Barbara A Centeno
  • Jennifer Permuth-Wey
  • Jose M Pimiento
  • Mokenge Malafa

Abstract

The outcomes of patients treated with surgery for early stage pancreatic ductal adenocarcinoma (PDAC) are variable with median survival ranging from 6 months to more than 5 years. This challenge underscores an unmet need for developing personalized medicine strategies to refine the current treatment decision-making process. To derive a prognostic gene signature for patients with early stage PDAC, a PDAC cohort from Moffitt Cancer Center (n = 63) was used with overall survival (OS) as the primary endpoint. This was further evaluated using an independent microarray cohort dataset (Stratford et al: n = 102). Technical validation was performed by NanoString platform. A prognostic 15-gene signature was developed and showed a statistically significant association with OS in the Moffitt cohort (hazard ratio [HR] = 3.26; p

Suggested Citation

  • Dung-Tsa Chen & Ashley H Davis-Yadley & Po-Yu Huang & Kazim Husain & Barbara A Centeno & Jennifer Permuth-Wey & Jose M Pimiento & Mokenge Malafa, 2015. "Prognostic Fifteen-Gene Signature for Early Stage Pancreatic Ductal Adenocarcinoma," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-17, August.
    • Handle: RePEc:plo:pone00:0133562
    DOI: 10.1371/journal.pone.0133562
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