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Enrichment of Minor Alleles of Common SNPs and Improved Risk Prediction for Parkinson's Disease

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  • Zuobin Zhu
  • Dejian Yuan
  • Denghui Luo
  • Xitong Lu
  • Shi Huang

Abstract

Parkinson disease (PD) is the second most common neurodegenerative disorder in the aged population and thought to involve many genetic loci. While a number of individual single nucleotide polymorphisms (SNPs) have been linked with PD, many remain to be found and no known markers or combinations of them have a useful predictive value for sporadic PD cases. The collective effects of genome wide minor alleles of common SNPs, or the minor allele content (MAC) in an individual, have recently been shown to be linked with quantitative variations of numerous complex traits in model organisms with higher MAC more likely linked with lower fitness. Here we found that PD cases had higher MAC than matched controls. A set of 37564 SNPs with MA (MAF

Suggested Citation

  • Zuobin Zhu & Dejian Yuan & Denghui Luo & Xitong Lu & Shi Huang, 2015. "Enrichment of Minor Alleles of Common SNPs and Improved Risk Prediction for Parkinson's Disease," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-11, July.
    • Handle: RePEc:plo:pone00:0133421
    DOI: 10.1371/journal.pone.0133421
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