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Early Myocardial Repolarization Heterogeneity Is Detected by Magnetocardiography in Diabetic Patients with Cardiovascular Risk Factors

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  • Yi-Cheng Chang
  • Chau-Chung Wu
  • Chih-Hung Lin
  • Yen-Wen Wu
  • Ying-Chieh Yang
  • Tien-Jyun Chang
  • Yi-Der Jiang
  • Lee-Ming Chuang

Abstract

Multi-channel magnetocardiography (MCG) is a sensitive technique to map spatial ventricular repolarization with high resolution and reproducibility. Spatial ventricular repolarization heterogeneity measured by MCG has been shown to accurately detect and localize myocardial ischemia. Here, we explored whether these measurements correlated with cardiovascular risk factors in patients with type 2 diabetes. Two hundreds and seventy-seven type 2 diabetic patients without known coronary artery disease (CAD) and arrhythmia were recruited consecutively from the outpatient clinic of National Taiwan University Hospital. The spatially distributed QTc contour maps were constructed with 64-channel MCG using the superconducting quantum interference device (SQUID) system. Indices of myocardial repolarization heterogeneity including the smoothness index of QTc (SI-QTc) and QTc dispersion were derived and analyzed for association with conventional cardiovascular risk factors. SI-QTc correlated strongly with the QTc dispersion (r = 0.70, p

Suggested Citation

  • Yi-Cheng Chang & Chau-Chung Wu & Chih-Hung Lin & Yen-Wen Wu & Ying-Chieh Yang & Tien-Jyun Chang & Yi-Der Jiang & Lee-Ming Chuang, 2015. "Early Myocardial Repolarization Heterogeneity Is Detected by Magnetocardiography in Diabetic Patients with Cardiovascular Risk Factors," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0133192
    DOI: 10.1371/journal.pone.0133192
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