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Trends in Incidence Rates during 1999-2008 and Prevalence in 2008 of Childhood Type 1 Diabetes Mellitus in GERMANY – Model-Based National Estimates

Author

Listed:
  • Alexander Bendas
  • Ulrike Rothe
  • Wieland Kiess
  • Thomas Michael Kapellen
  • Thoralf Stange
  • Ulf Manuwald
  • Eckhard Salzsieder
  • Reinhard Walter Holl
  • Olaf Schoffer
  • Anna Stahl-Pehe
  • Guido Giani
  • Stefan Ehehalt
  • Andreas Neu
  • Joachim Rosenbauer

Abstract

Aims: To estimate the national incidence rate and trend of type 1 diabetes (T1DM) in Germany from 1999 to 2008 and the national prevalence in 2008 in the age group 0–14 years. Methods: Data were taken from a nationwide registry for incident cases of T1DM in the ages 0–4 years and 3 regional registries (North-Rhine-Westphalia, Baden-Wuerttemberg and Saxony) for incident cases of T1DM in the ages 0–14 years covering 41% of the child population in Germany. The degree of ascertainment was ≥ 97% in all registries. Incident and prevalent cases were grouped by region, sex, age (0–4, 5–9, 10–14 years), and, for incident data, additionally by two 5-year periods (1999–2003, 2004–2008). Poisson regression models were fitted to the data to derive national estimates of incidence rate trends and prevalence in the age groups 5–9, 10–14 and 0–14 years. We used direct age-standardization. Results: The estimated national incidence rate in 0-14-year-olds increased significantly by 18.1% (95%CI: 11.6–25.0%, p

Suggested Citation

  • Alexander Bendas & Ulrike Rothe & Wieland Kiess & Thomas Michael Kapellen & Thoralf Stange & Ulf Manuwald & Eckhard Salzsieder & Reinhard Walter Holl & Olaf Schoffer & Anna Stahl-Pehe & Guido Giani & , 2015. "Trends in Incidence Rates during 1999-2008 and Prevalence in 2008 of Childhood Type 1 Diabetes Mellitus in GERMANY – Model-Based National Estimates," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0132716
    DOI: 10.1371/journal.pone.0132716
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