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Alterations in Activation, Cytotoxic Capacity and Trafficking Profile of Peripheral CD8 T Cells in Young Adult Binge Drinkers

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  • José Luis Zaldivar Fujigaki
  • América Guadalupe Arroyo Valerio
  • Juan Carlos López Alvarenga
  • Esperanza Gabriela Gutiérrez Reyes
  • David Kershenobich
  • Joselin Hernández Ruiz

Abstract

Background: Excess of alcohol consumption is a public health problem and has documented effects on the immune system of humans and animals. Animal and in vitro studies suggest that alcohol abuse changes CD8 T cell (CD8) characteristics, however it remains unknown if the CD8 profile of binge drinkers is different in terms of activation, trafficking and cytotoxic capacity. Aim: To analyze the peripheral CD8 cytotoxic capacity, activation and trafficking phenotypic profile of Mexican young adults with regard to alcohol consumption pattern. Methods: 55 Mexican young adults were stratified as Light (20), Intermediate (18) or Binge drinkers (17) according to their reported alcohol consumption pattern. Blood samples were obtained and hematic biometry and liver enzyme analysis were performed. Peripheral CD8 profile was established by expression of Granzyme B (GB), CD137, CD127, CD69, TLR4, PD1, CCR2, CCR4, CCR5 and CXCR4 by FACS. Data was analyzed by ANOVA, posthoc DMS and Tamhane, and principal component analysis (PCA) with varimax rotation, p

Suggested Citation

  • José Luis Zaldivar Fujigaki & América Guadalupe Arroyo Valerio & Juan Carlos López Alvarenga & Esperanza Gabriela Gutiérrez Reyes & David Kershenobich & Joselin Hernández Ruiz, 2015. "Alterations in Activation, Cytotoxic Capacity and Trafficking Profile of Peripheral CD8 T Cells in Young Adult Binge Drinkers," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-13, July.
    • Handle: RePEc:plo:pone00:0132521
    DOI: 10.1371/journal.pone.0132521
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