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High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes

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  • Qian Huang
  • Guilian Shang
  • Haohua Deng
  • Jie Liu
  • Yan Mei
  • Yancheng Xu

Abstract

Objective: To investigate mannose-binding lectin (MBL) serum levels in type 2 diabetic patients with and without diabetic retinopathy (DR). Methods: Serum MBL levels were determined in type 2 diabetic patients (N=324) as well as in 300 healthy control Subjects. Multivariate analyses were performed using logistic regression models. Receiver operating characteristic curves (ROC) was used to test the overall predict accuracy of MBL and other markers. Results: Diabetic patients with DR and vision-threatening diabetic retinopathy (VTDR) had significantly higher MBL levels on admission (P

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  • Qian Huang & Guilian Shang & Haohua Deng & Jie Liu & Yan Mei & Yancheng Xu, 2015. "High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0130665
    DOI: 10.1371/journal.pone.0130665
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