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Prophylactic Effect of Lamivudine for Chemotherapy-Induced Hepatitis B Reactivation in Breast Cancer: A Meta-Analysis

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  • Wei Tang
  • Lun Chen
  • Ruohui Zheng
  • Lingxiao Pan
  • Jin Gao
  • Xigang Ye
  • Xiaoshen Zhang
  • Wenbo Zheng

Abstract

Background: Three strategies using lamivudine have been proposed to prevent chemotherapy-induced HBV (hepatitis B virus) reactivation in the clinical setting. The purpose of this meta-analysis is to evaluate the efficacy of the early preemptive strategy, deferred preemptive strategy and therapeutic strategy in patients with HBsAg-positive breast cancer during chemotherapy. Methods: Clinical studies published from database inception until Nov 1, 2014, were included for analysis. The primary outcomes were overall survival, rate of chemotherapy disruption and virological and clinical reactivation. The secondary outcomes were the rates of HBV-related chemotherapy disruption, HBV-related mortality, YMDD mutations and withdrawal hepatitis. Results: Four hundred and thirty patients in four studies that compared the early preemptive strategy with a therapeutic strategy were included. Application of early preemptive lamivudine was superior in reducing HBV recurrence (pooled OR: 0.12, 95% CI, 0.04 to 0.31, P

Suggested Citation

  • Wei Tang & Lun Chen & Ruohui Zheng & Lingxiao Pan & Jin Gao & Xigang Ye & Xiaoshen Zhang & Wenbo Zheng, 2015. "Prophylactic Effect of Lamivudine for Chemotherapy-Induced Hepatitis B Reactivation in Breast Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0128673
    DOI: 10.1371/journal.pone.0128673
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