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Meta-Analysis-Based Preliminary Exploration of the Connection between ATDILI and Schizophrenia by GSTM1/T1 Gene Polymorphisms

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Listed:
  • Lei Cai
  • Mei-Hong Cai
  • Mei-Yan Wang
  • Yi-Feng Xu
  • Wen-Zhong Chen
  • Shen-Ying Qin
  • Chun-Ling Wan
  • Lin He

Abstract

Anti-tuberculosis drugs have some adverse effects such as anti-tuberculosis drug-induced liver injury (ATDILI) and mental disorders. The involvement of glutathione S-transferase (GST) genes in pathogenesis of ATDILI or schizophrenia (SCZ) has been reported. Therefore, GST genes may exemplify molecular connectors between ATDILI and SCZ. However, association studies of GSTM1/T1 polymorphisms with these two diseases have yielded conflicting results. After searching case-control association studies in PubMed, ISI Web of Science, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Chinese BioMedical Literature Database, we performed meta-analyses across a total of 20 published association studies on 3146 subjects for the association of GSTM1 and ATDILI, 2587 for the GSTT1-ATDILI association, 2283 for GSTM1-SCZ and 1116 for GSTT1-SCZ to test the associations of GSTM1/T1 polymorphisms with ATDILI and SCZ. The GSTM1 present genotype was significantly associated with decreased risks of ATDILI (risk ratio(RR): 0.81, 95% confidence interval (CI): 0.75–0.88, P

Suggested Citation

  • Lei Cai & Mei-Hong Cai & Mei-Yan Wang & Yi-Feng Xu & Wen-Zhong Chen & Shen-Ying Qin & Chun-Ling Wan & Lin He, 2015. "Meta-Analysis-Based Preliminary Exploration of the Connection between ATDILI and Schizophrenia by GSTM1/T1 Gene Polymorphisms," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0128643
    DOI: 10.1371/journal.pone.0128643
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    1. Yu Cai & JiaYong Yi & ChaoHui Zhou & XiZhong Shen, 2012. "Pharmacogenetic Study of Drug-Metabolising Enzyme Polymorphisms on the Risk of Anti-Tuberculosis Drug-Induced Liver Injury: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-8, October.
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