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Effect of Dexmedetomidine on Preventing Postoperative Agitation in Children: A Meta-Analysis

Author

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  • Juan Ni
  • Jiafu Wei
  • Yusheng Yao
  • Xiaoqin Jiang
  • Linli Luo
  • Dong Luo

Abstract

Background: Emergence agitation (EA) is one of the most common postoperative complications in children. The purpose of this meta-analysis is to assess the effect of dexmedetomidine for preventing postoperative agitation in children. Methods: We searched the Cochrane Central Register of Controlled Trails, MEDLINE, and EMBASE. Randomized controlled trials were included. The following outcome measures were evaluated: incidence of EA, number of patients requiring rescue, time to eye-open, time to extubation, time to discharge from the postanesthesia care unit (PACU). Results: We analyzed 19 trials (1608 patients) that met the inclusion criteria. Compared with placebo, intravenous dexmedetomidine significantly reduced the incidence of EA [risk ratio (RR) 0.34, 95% confidence interval (CI) 0.25–0.44, P

Suggested Citation

  • Juan Ni & Jiafu Wei & Yusheng Yao & Xiaoqin Jiang & Linli Luo & Dong Luo, 2015. "Effect of Dexmedetomidine on Preventing Postoperative Agitation in Children: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0128450
    DOI: 10.1371/journal.pone.0128450
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    Cited by:

    1. Fu-Wei Chiang & Jin-Lin Chang & Shih-Chang Hsu & Kuo-Yuan Hsu & Karen Chia-Wen Chu & Chun-Jen Huang & Chyi-Huey Bai & Chiehfeng Chen & Chin-Wang Hsu & Yuan-Pin Hsu, 2020. "Dexmedetomidine use in pediatric strabismus surgery: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-20, October.

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