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Opioids Contribute to Fracture Risk: A Meta-Analysis of 8 Cohort Studies

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Listed:
  • Zhaowei Teng
  • Yun Zhu
  • Feihu Wu
  • Yanhong Zhu
  • Xiguang Zhang
  • Chuanlin Zhang
  • Shuangneng Wang
  • Lei Zhang

Abstract

Objective: To evaluate the association between chronic opioid use for non-cancer pain and fracture risk by conducting a meta-analysis of cohort studies. Methods: Cohort studies were identified by searching PubMed and EMBASE from their inception to July 2014. A fracture was considered an endpoint. The information was extracted by two authors independently. When the heterogeneity was significant, a random-effects model was used to calculate the overall pooled risk estimates. Results: Eight cohort studies were included in the final meta-analysis. On the basis of the Newcastle-Ottawa Scale (NOS), six studies were considered to be of high quality. The overall combined relative risk for the use of opioids and fractures was 1.88 (95% confidence interval [CI] 1.51-2.34). A subgroup analysis revealed the sources of heterogeneity. The sensitivity analysis indicated stable results, and no publication bias was observed. Conclusions: This meta-analysis of cohort studies demonstrates that opioids significantly increase the risk of fractures.

Suggested Citation

  • Zhaowei Teng & Yun Zhu & Feihu Wu & Yanhong Zhu & Xiguang Zhang & Chuanlin Zhang & Shuangneng Wang & Lei Zhang, 2015. "Opioids Contribute to Fracture Risk: A Meta-Analysis of 8 Cohort Studies," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-13, June.
    • Handle: RePEc:plo:pone00:0128232
    DOI: 10.1371/journal.pone.0128232
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    Cited by:

    1. Qiaoning Yue & Yue Ma & Yirong Teng & Yun Zhu & Hao Liu & Shuanglan Xu & Jie Liu & Jianping Liu & Xiguang Zhang & Zhaowei Teng, 2020. "An updated analysis of opioids increasing the risk of fractures," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-12, April.

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