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Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis

Author

Listed:
  • Mu-xing Li
  • Xin-yu Bi
  • Zhen Huang
  • Jian-jun Zhao
  • Yue Han
  • Zhi-yu Li
  • Ye-fan Zhang
  • Yuan Li
  • Xiao Chen
  • Xu-hui Hu
  • Hong Zhao
  • Jian-qiang Cai

Abstract

Objective: The definite prognostic role of p-STAT3 has not been well defined. We performed a meta-analysis evaluating the prognostic role of p-STAT3 expression in patients with digestive system cancers. Methods: We searched the available articles reporting the prognostic value of p-STAT3 in patients with cancers of the digestive system, mainly including colorectal cancer, gastric cancer, hepatocellular carcinoma, esophagus cancer and pancreatic cancer. The pooled hazard ratios (HRs) with 95 % confidence intervals (95 % CIs) of overall survival (OS) and disease-free survival (DFS) were used to assess the prognostic role of p-STAT3 expression level in cancer tissues. And the association between p-STAT3 expression and clinicopathological characteristics was evaluated. Results: A total of 22 studies with 3585 patients were finally enrolled in the meta-analysis. The results showed that elevated p-STAT3 expression level predicted inferior OS (HR=1.809, 95% CI: 1.442-2.270, P

Suggested Citation

  • Mu-xing Li & Xin-yu Bi & Zhen Huang & Jian-jun Zhao & Yue Han & Zhi-yu Li & Ye-fan Zhang & Yuan Li & Xiao Chen & Xu-hui Hu & Hong Zhao & Jian-qiang Cai, 2015. "Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-16, May.
    • Handle: RePEc:plo:pone00:0127356
    DOI: 10.1371/journal.pone.0127356
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