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Clinical Predictors of Survival for Patients with Stage IV Cancer Referred to Radiation Oncology

Author

Listed:
  • Johnny Kao
  • Kenneth D Gold
  • Gina Zarrili
  • Emily Copel
  • Andrew J Silverman
  • Shanata S Ramsaran
  • David Yens
  • Samuel Ryu

Abstract

Background: There is an urgent need for a robust, clinically useful predictive model for survival in a heterogeneous group of patients with metastatic cancer referred to radiation oncology. Methods: From May 2012 to August 2013, 143 consecutive patients with stage IV cancer were prospectively evaluated by a single radiation oncologist. We retrospectively analyzed the effect of 29 patient, laboratory and tumor-related prognostic factors on overall survival using univariate analysis. Variables that were statistically significant on univariate analysis were entered into a multivariable Cox regression to identify independent predictors of overall survival. Results: The median overall survival was 5.5 months. Four prognostic factors significantly predicted survival on multivariable analysis including ECOG performance status (0–1 vs. 2 vs. 3–4), number of active tumors (1 to 5 vs. ≥6), albumin levels (≥3.4 vs. 2.4 to 3.3 vs. 31.4 months for very low risk patients compared to 14.5 months for low risk, 4.1 months for intermediate risk and 1.2 months for high risk (p

Suggested Citation

  • Johnny Kao & Kenneth D Gold & Gina Zarrili & Emily Copel & Andrew J Silverman & Shanata S Ramsaran & David Yens & Samuel Ryu, 2015. "Clinical Predictors of Survival for Patients with Stage IV Cancer Referred to Radiation Oncology," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-11, April.
    • Handle: RePEc:plo:pone00:0124329
    DOI: 10.1371/journal.pone.0124329
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