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A Comparison of Disease Burden in Rheumatoid Arthritis, Psoriatic Arthritis and Axial Spondyloarthritis

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Listed:
  • Brigitte Michelsen
  • Ragnhild Fiane
  • Andreas P Diamantopoulos
  • Dag Magnar Soldal
  • Inger Johanne W Hansen
  • Tuulikki Sokka
  • Arthur Kavanaugh
  • Glenn Haugeberg

Abstract

Objective: The main objective of this study was to compare disease burden in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (ax-SpA). Methods: In this cross-sectional study, all the RA (1093), PsA (365) and ax-SpA (333) patients who visited the out-patient clinic of the Hospital of Southern Norway Trust during the year 2013 were included; the RA patients all had a RA diagnosis verified by the treating rheumatologist, the PsA patients all fulfilled the ClASsification for Psoriatic ARthritis (CASPAR) criteria and the ax-SpA patients all fulfilled the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for ax-SpA. Patient-reported health status, demographic variables, medications, and composite scores of disease activity were assessed. The main analyses were performed using General Linear Models adjusted for age, sex and multiple comparisons. Correlation analyses were performed using Spearman’s rho. Results: The reported pain, joint pain, patient’s global assessment and fatigue were similar in PsA and ax-SpA, but significantly lower in RA. The 28-joint Disease Activity Score (DAS28) (0.3±0.1, p = 0.003), Clinical Disease Activity Index (CDAI) (1.0±0.4, p = 0.028) and Routine Assessment of Patient Index Data 3 (RAPID3) (0.4±0.1, p = 0.004) were all significantly higher in PsA vs. RA. RAPID3 showed moderate to high correlation with DAS28 (rho = 0.521, p

Suggested Citation

  • Brigitte Michelsen & Ragnhild Fiane & Andreas P Diamantopoulos & Dag Magnar Soldal & Inger Johanne W Hansen & Tuulikki Sokka & Arthur Kavanaugh & Glenn Haugeberg, 2015. "A Comparison of Disease Burden in Rheumatoid Arthritis, Psoriatic Arthritis and Axial Spondyloarthritis," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-11, April.
    • Handle: RePEc:plo:pone00:0123582
    DOI: 10.1371/journal.pone.0123582
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    Cited by:

    1. Trine Pilgaard & Lise Hagelund & Sandra Elkjær Stallknecht & Henrik Holm Jensen & Bente Appel Esbensen, 2019. "Severity of fatigue in people with rheumatoid arthritis, psoriatic arthritis and spondyloarthritis – Results of a cross-sectional study," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-13, June.

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