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Plasma Levels of microRNA-145 Are Associated with Severity of Coronary Artery Disease

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  • Hai Gao
  • Raviteja Reddy Guddeti
  • Yasushi Matsuzawa
  • Li-Ping Liu
  • Li-Xiao Su
  • Duo Guo
  • Shao-Ping Nie
  • Jie Du
  • Ming Zhang

Abstract

Background and Objective: MicroRNAs (miRNAs) have been shown to be associated with various physiological and pathological conditions, including inflammation and cardiovascular disease, but little is known about their relationship with the presence of coronary artery disease (CAD) and disease severity. Methods: A total of 195 consecutive subjects who underwent coronary angiography for chest pain evaluation were enrolled in this study. In CAD patients severity of coronary lesions was assessed by the number of diseased vessels and the Synergy between PCI with Taxus and Cardiac surgery score (SYNTAX score). Plasma levels of miRNA-145 were quantified by real-time quantitative polymerase chain reaction test, and logarithmic transformation of miRNA-145 levels (Ln_miRNA-145) was used for analyses due to its skewed distribution. Results: Of the 195 total subjects 167 patients were diagnosed as having CAD. Ln_miRNA-145 was significantly lower in CAD patients compared with the non-CAD group (-6.11±0.92 vs. -5.06±1.25; p

Suggested Citation

  • Hai Gao & Raviteja Reddy Guddeti & Yasushi Matsuzawa & Li-Ping Liu & Li-Xiao Su & Duo Guo & Shao-Ping Nie & Jie Du & Ming Zhang, 2015. "Plasma Levels of microRNA-145 Are Associated with Severity of Coronary Artery Disease," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0123477
    DOI: 10.1371/journal.pone.0123477
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    References listed on IDEAS

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    1. Kimberly R. Cordes & Neil T. Sheehy & Mark P. White & Emily C. Berry & Sarah U. Morton & Alecia N. Muth & Ting-Hein Lee & Joseph M. Miano & Kathryn N. Ivey & Deepak Srivastava, 2009. "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity," Nature, Nature, vol. 460(7256), pages 705-710, August.
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