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Fetal Calcifications Are Associated with Chromosomal Abnormalities

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  • Ellika Sahlin
  • Meeli Sirotkina
  • Andreas Marnerides
  • Erik Iwarsson
  • Nikos Papadogiannakis

Abstract

Objective: The biological importance of calcifications occasionally noted in fetal tissues (mainly liver) at autopsy or ultrasound is largely unexplored. Previous reports hint at an association to infection, circulatory compromise, malformations or chromosomal abnormalities. To identify factors associated with calcifications, we have performed a case-control study on the largest cohort of fetuses with calcifications described thus far. Methods: One-hundred and fifty-one fetuses with calcifications and 302 matched controls were selected from the archives of the Department of Pathology, Karolinska University Hospital. Chromosome analysis by karyotyping or quantitative fluorescence-polymerase chain reaction was performed. Autopsy and placenta reports were scrutinized for presence of malformations and signs of infection. Results: Calcifications were mainly located in the liver, but also in heart, bowel, and other tissues. Fetuses with calcifications showed a significantly higher proportion of chromosomal abnormalities than controls; 50% vs. 20% (p

Suggested Citation

  • Ellika Sahlin & Meeli Sirotkina & Andreas Marnerides & Erik Iwarsson & Nikos Papadogiannakis, 2015. "Fetal Calcifications Are Associated with Chromosomal Abnormalities," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0123343
    DOI: 10.1371/journal.pone.0123343
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