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The Predictive Value of Serum Squamous Cell Carcinoma Antigen in Patients with Cervical Cancer Who Receive Neoadjuvant Chemotherapy followed by Radical Surgery: A Single-Institute Study

Author

Listed:
  • Xiong Li
  • Jin Zhou
  • Kecheng Huang
  • Fangxu Tang
  • Hang Zhou
  • Shaoshuai Wang
  • Yao Jia
  • Haiying Sun
  • Ding Ma
  • Shuang Li

Abstract

Objective: Neoadjuvant chemotherapy (NACT) could affect the levels of squamous cell carcinoma antigen (SCC-Ag). This study evaluates the predictive value of pre- and posttreatment SCC-Ag levels in patients with cervical cancer who were treated with NACT followed by radical surgery. Methods: A total of 286 patients with Stage IB1-IIIB squamous cell carcinoma of the uterine cervix who were treated with NACT followed by radical hysterectomy were analyzed retrospectively. The relationship between SCC-Ag levels, the clinicopathologic parameters, the response to NACT and the three-year survival rate was investigated. Results: The levels of SCC-Ag were elevated (>3.5 ng/mL) in 43.8% of patients before NACT, and 13.0% of patients after NACT. Pre- and posttreatment levels of SCC-Ag correlated with the response to NACT (P = 0.010, and P 3.5 ng/mL (P 3.5 ng/mL) indicated a poor response to NACT and a higher risk of lymph node metastases. Elevated posttreatment levels of SCC-Ag were correlated with poor DFS and OS.

Suggested Citation

  • Xiong Li & Jin Zhou & Kecheng Huang & Fangxu Tang & Hang Zhou & Shaoshuai Wang & Yao Jia & Haiying Sun & Ding Ma & Shuang Li, 2015. "The Predictive Value of Serum Squamous Cell Carcinoma Antigen in Patients with Cervical Cancer Who Receive Neoadjuvant Chemotherapy followed by Radical Surgery: A Single-Institute Study," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-12, April.
    • Handle: RePEc:plo:pone00:0122361
    DOI: 10.1371/journal.pone.0122361
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