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Primary Treatment Response Rather than Front Line Stem Cell Transplantation Is Crucial for Long Term Outcome of Peripheral T-Cell Lymphomas

Author

Listed:
  • Giuseppe Gritti
  • Cristina Boschini
  • Andrea Rossi
  • Federica Delaini
  • Anna Grassi
  • Alessandra Algarotti
  • Caterina Micò
  • Rosangela Trezzi
  • Andrea Gianatti
  • Anna Maria Barbui
  • Alessandro Rambaldi

Abstract

Outcome of systemic peripheral T-cell lymphomas (PTCL) is unsatisfactory and no controlled clinical study guides the therapy. Phase II studies suggest to consolidate response achieved after front-line treatment with stem cell transplant (SCT). We retrospectively evaluate the impact of front-line SCT consolidation in a single Center cohort of 209 patients treated during the last two decades. Median age was 49 years (range 15-85) with a prevalence of male sex (61%), advanced stage (68%) while IPI was >2 in 44%. Primary treatment was MACOP-B (39%) CHO(E)P (39%), intensive regimens (18%) or others (4%). Complete response to primary treatment (i.e. before SCT) was 60% (5% partial remission). Forty-four patients further proceeded to SCT while 92 did not receive consolidation. Outcome of primary responders was good, with a 3-year overall survival of 74% (82% in ALCL ALK+ and 69% for the other histologies). By multivariate analysis a better overall survival was significantly associated with IPI

Suggested Citation

  • Giuseppe Gritti & Cristina Boschini & Andrea Rossi & Federica Delaini & Anna Grassi & Alessandra Algarotti & Caterina Micò & Rosangela Trezzi & Andrea Gianatti & Anna Maria Barbui & Alessandro Rambald, 2015. "Primary Treatment Response Rather than Front Line Stem Cell Transplantation Is Crucial for Long Term Outcome of Peripheral T-Cell Lymphomas," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0121822
    DOI: 10.1371/journal.pone.0121822
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