IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0119846.html
   My bibliography  Save this article

Cardiac Microvascular Barrier Function Mediates the Protection of Tongxinluo against Myocardial Ischemia/Reperfusion Injury

Author

Listed:
  • Kang Qi
  • Lujin Li
  • Xiangdong Li
  • Jinglin Zhao
  • Yang Wang
  • Shijie You
  • Fenghuan Hu
  • Haitao Zhang
  • Yutong Cheng
  • Sheng Kang
  • Hehe Cui
  • Lian Duan
  • Chen Jin
  • Qingshan Zheng
  • Yuejin Yang

Abstract

Objective: Tongxinluo (TXL) has been shown to decrease myocardial necrosis after ischemia/reperfusion (I/R) by simulating ischemia preconditioning (IPC). However, the core mechanism of TXL remains unclear. This study was designed to investigate the key targets of TXL against I/R injury (IRI) among the cardiac structure-function network. Materials and Methods: To evaluate the severity of lethal IRI, a mathematical model was established according to the relationship between myocardial no-reflow size and necrosis size. A total of 168 mini-swine were employed in myocardial I/R experiment. IRI severity among different interventions was compared and IPC and CCB groups were identified as the mildest and severest groups, respectively. Principal component analysis was applied to further determine 9 key targets of IPC in cardioprotection. Then, the key targets of TXL in cardioprotection were confirmed. Results: Necrosis size and no-reflow size fit well with the Sigmoid Emax model. Necrosis reduction space (NRS) positively correlates with I/R injury severity and necrosis size (R2=0.92, R2=0.57, P 0.05) or CCB (P

Suggested Citation

  • Kang Qi & Lujin Li & Xiangdong Li & Jinglin Zhao & Yang Wang & Shijie You & Fenghuan Hu & Haitao Zhang & Yutong Cheng & Sheng Kang & Hehe Cui & Lian Duan & Chen Jin & Qingshan Zheng & Yuejin Yang, 2015. "Cardiac Microvascular Barrier Function Mediates the Protection of Tongxinluo against Myocardial Ischemia/Reperfusion Injury," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-24, March.
    • Handle: RePEc:plo:pone00:0119846
    DOI: 10.1371/journal.pone.0119846
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119846
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0119846&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0119846?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sara M. Weis & David A. Cheresh, 2005. "Pathophysiological consequences of VEGF-induced vascular permeability," Nature, Nature, vol. 437(7058), pages 497-504, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Judy R. Beijnum & Elisabeth J. M. Huijbers & Karlijn Loon & Athanasios Blanas & Parvin Akbari & Arno Roos & Tse J. Wong & Stepan S. Denisov & Tilman M. Hackeng & Connie R. Jimenez & Patrycja Nowak-Sli, 2022. "Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0119846. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.