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Genetic Association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1/SIX6 with the Endophenotypes of Primary Open Angle Glaucoma in Indian Population

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  • Ferdinamarie Sharmila Philomenadin
  • Rashima Asokan
  • Viswanathan N
  • Ronnie George
  • Vijaya Lingam
  • Sripriya Sarangapani

Abstract

Primary open angle glaucoma (POAG) belonging to a group of optic neuropathies, result from interaction between genetic and environmental factors. Study of associations with quantitative traits (QTs) is one of the successful strategies to understand the complex genetics of POAG. The current study attempts to explore the association of variations near/in genes like ATOH7, SIX1/SIX6 complex, CDKN2B, CARD10, and CDC7 with POAG and its QTs including vertical cup to disc ratio (VCDR), central corneal thickness (CCT), intra ocular pressure (IOP), and axial length (AL). Case-control study design was carried out in a sample size of 97 POAG cases and 371 controls from South India. Model-based (additive, recessive, dominant) association of the genotypes and their interaction was carried out between cases and controls using chi-square, linear and logistic regression methods. Nominal significance (P

Suggested Citation

  • Ferdinamarie Sharmila Philomenadin & Rashima Asokan & Viswanathan N & Ronnie George & Vijaya Lingam & Sripriya Sarangapani, 2015. "Genetic Association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1/SIX6 with the Endophenotypes of Primary Open Angle Glaucoma in Indian Population," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0119703
    DOI: 10.1371/journal.pone.0119703
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