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Gender Differences in the Risk Factors for Endothelial Dysfunction in Chinese Hypertensive Patients: Homocysteine Is an Independent Risk Factor in Females

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Listed:
  • Cheng Cao
  • Jianxin Hu
  • Yifei Dong
  • Rui Zhan
  • Ping Li
  • Hai Su
  • Qiang Peng
  • Tao Wu
  • Liang Lei
  • Xiao Huang
  • Qinghua Wu
  • Xiaoshu Cheng

Abstract

Objectives: Endothelial dysfunction plays a key role in the pathogenesis of cardiovascular disease. However, the gender-related differences in risk factors for endothelial dysfunction are controversial. We investigated the gender differences in the risk factor profiles for endothelial dysfunction in Chinese hypertensive patients. Methods: Vascular endothelial functions in 213 hypertensive patients were measured by digital reactive hyperemia peripheral arterial tonometry (RH-PAT). Peripheral blood samples were collected, and the self-reported smoking and alcohol consumption status, age, body mass index, heart rate, blood pressure and drug administrations were recorded. Results: RH-PAT indexes were attenuated in both male and female hypertensive patients [1.60 (1.38-2.02) vs. 1.63 (1.44-1.98)]. Multivariate logistic regression analysis identified plasma creatinine (p

Suggested Citation

  • Cheng Cao & Jianxin Hu & Yifei Dong & Rui Zhan & Ping Li & Hai Su & Qiang Peng & Tao Wu & Liang Lei & Xiao Huang & Qinghua Wu & Xiaoshu Cheng, 2015. "Gender Differences in the Risk Factors for Endothelial Dysfunction in Chinese Hypertensive Patients: Homocysteine Is an Independent Risk Factor in Females," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0118686
    DOI: 10.1371/journal.pone.0118686
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