Author
Listed:
- Akiko Hata
- Koji Yonemoto
- Yosuke Shikama
- Nanako Aki
- Chisato Kosugi
- Ayako Tamura
- Takako Ichihara
- Takako Minagawa
- Yumi Kuwamura
- Masashi Miyoshi
- Takayuki Nakao
- Makoto Funaki
Abstract
Aim: To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers. Methods: A total of 365 subjects without MetS aged 20–60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS. Results: During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (≤ 4.9, 5.0–6.6, 6.7–8.8 and ≥ 8.9 μg/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02–0.78; P = 0.03) in subjects with total adiponectin level of 5.0–6.6 μg/ml, and 0.15 (95% CI 0.02–0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with those with total adiponectin level ≥ 8.9 μg/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 μg/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml (TR 0.22, 95% CI: 0.08–0.64, P = 0.005). Conclusion: Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 μg/ml in male Japanese workers. Subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 μg/ml.
Suggested Citation
Akiko Hata & Koji Yonemoto & Yosuke Shikama & Nanako Aki & Chisato Kosugi & Ayako Tamura & Takako Ichihara & Takako Minagawa & Yumi Kuwamura & Masashi Miyoshi & Takayuki Nakao & Makoto Funaki, 2015.
"Cut-Off Value of Total Adiponectin for Managing Risk of Developing Metabolic Syndrome in Male Japanese Workers,"
PLOS ONE, Public Library of Science, vol. 10(2), pages 1-10, February.
Handle:
RePEc:plo:pone00:0118373
DOI: 10.1371/journal.pone.0118373
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