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Irritable Brain Caused by Irritable Bowel? A Nationwide Analysis for Irritable Bowel Syndrome and Risk of Bipolar Disorder

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  • Chia-Jen Liu
  • Li-Yu Hu
  • Chiu-Mei Yeh
  • Yu-Wen Hu
  • Pan-Ming Chen
  • Tzeng-Ji Chen
  • Ti Lu

Abstract

Objective: We explored the association between IBS and the development of bipolar disorder, and the risk factors for bipolar disorders in patients with IBS. Methods: We identified patients who were newly diagnosed with IBS between 2000 and 2010 in the Taiwan National Health Insurance Research Database. We also identified a comparison matched cohort without IBS. The occurrence of new-onset bipolar disorder was evaluated in both cohorts. Results: The IBS cohort consisted of 30,796 patients and the comparison cohort consisted of 30,796 matched patients without IBS. The incidence of bipolar disorder (incidence rate ratio, 2.63, 95% confidence interval (CI) 2.10–3.31, P

Suggested Citation

  • Chia-Jen Liu & Li-Yu Hu & Chiu-Mei Yeh & Yu-Wen Hu & Pan-Ming Chen & Tzeng-Ji Chen & Ti Lu, 2015. "Irritable Brain Caused by Irritable Bowel? A Nationwide Analysis for Irritable Bowel Syndrome and Risk of Bipolar Disorder," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0118209
    DOI: 10.1371/journal.pone.0118209
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