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Diffusion Tensor Imaging Studies of Cervical Spondylotic Myelopathy: A Systemic Review and Meta-Analysis

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  • Xiaofei Guan
  • Guoxin Fan
  • Xinbo Wu
  • Guangfei Gu
  • Xin Gu
  • Hailong Zhang
  • Shisheng He

Abstract

A meta-analysis was conducted to assess alterations in measures of diffusion tensor imaging (DTI) in the patients of cervical spondylotic myelopathy (CSM), exploring the potential role of DTI as a diagnosis biomarker. A systematic search of all related studies written in English was conducted using PubMed, Web of Science, EMBASE, CINAHL, and Cochrane comparing CSM patients with healthy controls. Key details for each study regarding participants, imaging techniques, and results were extracted. DTI measurements, such as fractional anisotropy (FA), apparent diffusion coefficient (ADC), and mean diffusivity (MD) were pooled to calculate the effect size (ES) by fixed or random effects meta-analysis. 14 studies involving 479 CSM patients and 278 controls were identified. Meta-analysis of the most compressed levels (MCL) of CSM patients demonstrated that FA was significantly reduced (ES -1.52, 95% CI -1.87 to -1.16, P

Suggested Citation

  • Xiaofei Guan & Guoxin Fan & Xinbo Wu & Guangfei Gu & Xin Gu & Hailong Zhang & Shisheng He, 2015. "Diffusion Tensor Imaging Studies of Cervical Spondylotic Myelopathy: A Systemic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0117707
    DOI: 10.1371/journal.pone.0117707
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